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Food samples Two food samples, meatballs and eggs, rich sources for choline, l-carnitine, creatinine, and to some extent betaine, were used for the method optimization

Participation therein was voluntary

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Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease

Stroke 50 , 18051811 (2019)

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